Emil Alexov Selected Research

Snyder Robinson syndrome

1/2016	Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase.
1/2014	Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach.
9/2013	A Y328C missense mutation in spermine synthase causes a mild form of Snyder-Robinson syndrome.
7/2013	A rational free energy-based approach to understanding and targeting disease-causing missense mutations.
1/2013	Enhancing human spermine synthase activity by engineered mutations.
9/2010	Computational analysis of missense mutations causing Snyder-Robinson syndrome.

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Emil Alexov Research Topics

Disease

6	Snyder Robinson syndrome 01/2016 - 09/2010
4	Intellectual Disability (Idiocy) 01/2017 - 07/2013
2	Rett Syndrome (Rett's Disorder) 10/2016 - 10/2015
1	Opioid-Related Disorders (Opiate Addiction) 09/2021
1	Oculocutaneous albinism type 2 07/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2021
1	Breast Neoplasms (Breast Cancer) 09/2019
1	Smith-Lemli-Opitz Syndrome 01/2018
1	Neural Tube Defects (Exencephaly) 01/2018
1	Disease Susceptibility (Diathesis) 02/2016
1	Cohen syndrome 01/2014
1	Epilepsy (Aura) 01/2014
1	Scoliosis 01/2014
1	Neurocutaneous Syndromes (Phakomatoses) 01/2014
1	Dementia (Dementias) 01/2014
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2014
1	Berylliosis 01/2014
1	Neoplasms (Cancer) 01/2013
1	Osteoporosis 01/2013
1	Glioblastoma (Glioblastoma Multiforme) 01/2013
1	Facial Asymmetry 01/2013
1	Muscle Hypotonia (Hypotonia) 01/2013
1	Movement Disorders (Movement Disorder) 01/2013
1	Seizures (Absence Seizure) 10/2012
1	Channelopathies 10/2012
1	Atrial Fibrillation 10/2012
1	Cardiomegaly (Heart Hypertrophy) 10/2012

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 07/2021 - 09/2010
4	Spermine SynthaseIBA 01/2016 - 07/2013
3	Amino Acids FDA Link 01/2017 - 09/2010
2	EnzymesIBA 01/2014 - 01/2014
1	Opioid Receptors (Opioid Receptor)IBA 09/2021
1	Genetic Markers (Genetic Marker)IBA 09/2019
1	A-Form DNA (A-DNA)IBA 09/2019
1	CholesterolIBA 01/2018
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2018
1	AcetylglucosamineIBA 01/2017
1	O-GlcNAc transferaseIBA 01/2017
1	CytosineIBA 10/2016
1	Methyl-CpG-Binding Protein 2IBA 10/2015
1	GangliosidesIBA 01/2014
1	GlycolipidsIBA 01/2014
1	Glycoproteins (Glycoprotein)IBA 01/2014
1	SaltsIBA 01/2014
1	BerylliumIBA 01/2014
1	Presenilin-1IBA 01/2014
1	Peptides (Polypeptides)IBA 01/2014
1	Pharmaceutical PreparationsIBA 01/2014
1	HLA-DPw2 antigenIBA 01/2014
1	Nucleic AcidsIBA 01/2013
1	Tumor Biomarkers (Tumor Markers)IBA 01/2013
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 10/2012
1	SpermineIBA 09/2010